Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts.

ABSTRACT:

Background

Higher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk.

Objectives

To explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies.

Methods

Conditional logistic regression models were used to calculate multivariable-adjusted ORs and 95% CIs in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC; n-cases = 947, n-controls = 947) and the UK Biobank (UK-BB; n-cases = 2759, n-controls = 12,021) cohorts.

Results

In EPIC, nonalbumin-adjusted total serum calcium (a proxy of free calci

SUBMITTER: Karavasiloglou N 

PROVIDER: S-EPMC10131343 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature