Neurobehavioral sex-related differences in Nf1^+/- mice: female show a "camouflaging"-type behavior.

ABSTRACT:

Background

Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous disorder associated with neurodevelopmental disorders including autism spectrum disorder (ASD). This condition has been associated with an increase of gamma-aminobutyric acid (GABA) neurotransmission and, consequently, an excitation/inhibition imbalance associated with autistic-like behavior in both human and animal models. Here, we explored the influence of biological sex in the GABAergic system and behavioral alterations induced by the Nf1^+/- mutation in a murine model.

Methods

Juvenile male and female Nf1^+/- mice and their wild-type (WT) littermates were used. Hippocampus size was assessed by conventional toluidine blue staining and structural magnetic resonance imaging (MRI). H

SUBMITTER: Santos S 

PROVIDER: S-EPMC10131355 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature