Electrochemical aptasensor based on the engineered core-shell MOF nanostructures for the detection of tumor antigens.

ABSTRACT: It is essential to develop ultrasensitive biosensors for cancer detection and treatment monitoring. In the development of sensing platforms, metal-organic frameworks (MOFs) have received considerable attention as potential porous crystalline nanostructures. Core-shell MOF nanoparticles (NPs) have shown different diversities, complexities, and biological functionalities, as well as significant electrochemical (EC) properties and potential bio-affinity to aptamers. As a result, the developed core-shell MOF-based aptasensors serve as highly sensitive platforms for sensing cancer biomarkers with an extremely low limit of detection (LOD). This paper aimed to provide an overview of different strategies for improving selectivity, sensitivity, and signal strength of MOF nanostructures. Then, aptam

SUBMITTER: Khan S 

PROVIDER: S-EPMC10131368 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature