STIL/AURKA axis promotes cell proliferation by influencing primary cilia formation in bladder cancer.

ABSTRACT:

Background

The primary cilia (PC) is a microtubule-based and nonmotile organelle which protrudes from the surface of almost all mammalian cells. At present, PC has been found to be a deficiency or loss in multiple cancers. Restoring PC could be a novel targeting therapy strategy. Our research showed that PC was reduced in human bladder cancer (BLCA) cells, and PC deficiency promotes cell proliferation. However, the concrete mechanisms remain unknown. SCL/TAL1 interrupting locus (STIL), a PC-related protein, was screened in our previous study and could influence the cell cycle by regulating PC in tumor cells. In this study, we aimed to elucidate the function of STIL for PC to explore the underlying mechanism of PC in BLCA.

Methods

Public database analysis, western blot, and e

SUBMITTER: Li J 

PROVIDER: S-EPMC10131372 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature