Identification of mitophagy-related biomarkers and immune infiltration in major depressive disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) is a life-threatening and debilitating mental health condition. Mitophagy, a form of selective autophagy that eliminates dysfunctional mitochondria, is associated with depression. However, studies on the relationship between mitophagy-related genes (MRGs) and MDD are scarce. This study aimed to identify potential mitophagy-related biomarkers for MDD and characterize the underlying molecular mechanisms.

Methods

The gene expression profiles of 144 MDD samples and 72 normal controls were retrieved from the Gene Expression Omnibus database, and the MRGs were extracted from the GeneCards database. Consensus clustering was used to determine MDD clusters. Immune cell infiltration was evaluated using CIBERSORT. Functional enrichment analyse

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10131417 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature