An epigenome-wide analysis of socioeconomic position and tumor DNA methylation in breast cancer patients.

ABSTRACT:

Background

Disadvantaged socioeconomic position (SEP), including lower educational attainment and household income, may influence cancer risk and outcomes. We hypothesized that DNA methylation could function as an intermediary epigenetic mechanism that internalizes and reflects the biological impact of SEP.

Methods

Based on tumor DNA methylation data from the Illumina 450 K array from 694 breast cancer patients in the Women's Circle of Health Study, we conducted an epigenome-wide analysis in relation to educational attainment and household income. Functional impact of the identified CpG sites was explored in silico using data from publicly available databases.

Results

We identified 25 CpG sites associated with household income at an array-wide significance level, but

SUBMITTER: Chen J 

PROVIDER: S-EPMC10131486 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature