Hierarchical cue control of cocaine seeking in the face of cost.

ABSTRACT:

Rationale

Addiction is characterized by intermittent drug seeking despite rising costs. This behavior is heavily influenced by environmental stimuli that signal drug availability and reinforce drug seeking.

Objective

To establish the relationship between three key aspects of human drug use in rats: the intermittent, binge nature of drug intake, the motivational conflict of drug seeking in the face of escalating negative costs, and the ability of different drug cues to interact to modulate relapse.

Methods

Male and female rats were trained to self-administer cocaine on an intermittent access schedule, where brief drug-availability states were signaled by a shift in the ambient lighting of the environment, and cocaine infusions were signaled by a separate proximal discr

SUBMITTER: Collins V 

PROVIDER: S-EPMC10131580 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature