Multi-target antibacterial mechanism of ruthenium polypyridine complexes with anthraquinone groups against Staphylococcus aureus.

ABSTRACT: Three new Ru(ii) complexes, [Ru(dtb)₂PPAD](PF₆)₂ (Ru-1), [Ru(dmob)₂PPAD](PF₆)₂ (Ru-2) and [Ru(bpy)₂PPAD](PF₆)₂ (Ru-3) (dtb = 4,4'-di-tert-butyl-2,2'-bipyridine, dmob = 4,4'-dimethyl-2,2'-bipyridine, bpy = 2,2'-bipyridine and PPAD = 2-(pyridine-3-yl)-1H-imidazo[4,5f][1.10]phenanthracene-9,10-dione), were synthesized and characterized by ¹H NMR and ¹³C NMR spectroscopy, HRMS and HPLC. Among them, Ru-1 showed excellent antimicrobial activity against Gram-positive bacteria Staphylococcus aureus (minimum inhibitory concentration (MIC) = 1 μg mL^-1) and low hemolytic and cytotoxic activity. In addition, Ru-1<

SUBMITTER: Jiang L 

PROVIDER: S-EPMC10131643 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature