RND pumps across the genus Acinetobacter: AdeIJK is the universal efflux pump.

ABSTRACT: Acinetobacter are generally soil-dwelling organisms that can also cause serious human infections. A. baumannii is one of the most common causative agents of Acinetobacter infections and is often multidrug resistant. However, an additional 25 species within the genus have also been associated with infection. A. baumannii encodes six resistance nodulation division (RND) efflux pumps, the most clinically relevant class of efflux pumps for antibiotic export, but the distribution and types of RND efflux pumps across the genus is currently unknown. Sixty-four species making up the genus Acinetobacter were searched for RND systems within their genomes. We also developed a novel method using conserved RND residues to predict the total number of RND proteins inclu

SUBMITTER: Darby EM 

PROVIDER: S-EPMC10132057 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature