Dissemination of carbapenemase-producing <i>Enterobacterales</i> in Ireland from 2012 to 2017: a retrospective genomic surveillance study.

ABSTRACT: The spread of carbapenemase-producing Enterobacterales (CPE) is of major public health concern. The transmission dynamics of CPE in hospitals, particularly at the national level, are not well understood. Here, we describe a retrospective nationwide genomic surveillance study of CPE in Ireland between 2012 and 2017. We sequenced 746 national surveillance CPE samples obtained between 2012 and 2017. After clustering the sequences, we used thresholds based on pairwise SNPs, and reported within-host diversity along with epidemiological data to infer recent putative transmissions. All clusters in circulating clones, derived from high-resolution phylogenies, of a species (Klebsiella pneumoniae, Escherichia coli, Klebsiella oxytoca, Enterobacter cloacae, Enter

SUBMITTER: Hadjirin NF 

PROVIDER: S-EPMC10132065 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature