Global scenario of the RmtE pan-aminoglycoside-resistance mechanism: emergence of the <i>rmtE4</i> gene in South America associated with a hospital-related IncL plasmid.

ABSTRACT: Antimicrobial resistance (AMR) mechanisms, especially those conferring resistance to critically important antibiotics, are a great concern for public health. 16S rRNA methyltransferases (16S-RMTases) abolish the effectiveness of most clinically used aminoglycosides, but some of them are considered sporadic, such as RmtE. The main goals of this work were the genomic analysis of bacteria producing 16S-RMTases from a 'One Health' perspective in Venezuela, and the study of the epidemiological and evolutionary scenario of RmtE variants and their related mobile genetic elements (MGEs) worldwide. A total of 21 samples were collected in 2014 from different animal and environmental sources in the Cumaná region (Venezuela). Highly aminoglycoside-resistant Enterobacteriaceae isolates were sele

SUBMITTER: Delgado-Blas JF 

PROVIDER: S-EPMC10132066 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature