Using Budding Yeast as a Model to Understand Dynein-Mediated Cargo Transport.

ABSTRACT: Cytoplasmic dynein-1 is a minus end-directed microtubule motor that transports numerous cargoes in cell types throughout the evolutionary spectrum. Dynein is regulated by various motor-intrinsic and motor-extrinsic factors that enhance its processivity, recruit it to various cellular sites, or otherwise promote or restrict its activity. Studying dynein activity in higher eukaryotes is complicated by various factors, including the myriad functions in which this motor participates, and the consequential pleotropic effects associated with disrupting its activity. Budding yeast has long been a powerful model system for understanding this enormous motor protein complex, which is highly conserved between yeast and humans at the primary sequence and structural levels. Studies in budding yeast are

SUBMITTER: Ecklund KH 

PROVIDER: S-EPMC10132083 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature