Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations.

ABSTRACT: Regular exercise leads to widespread salutary effects, and there is increasing recognition that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited data exist regarding the plasma proteomic changes that occur in response to regular exercise. Here, we perform large-scale plasma proteomic profiling in 654 healthy human study participants before and after a supervised, 20-week endurance exercise training intervention. We identify hundreds of circulating proteins that are modulated, many of which are known to be secreted. We highlight proteins involved in angiogenesis, iron homeostasis, and the extracellular matrix, many of which are novel, including training-induced increases in fibroblast activation protein (FAP), a membrane-bound and circulating protei

SUBMITTER: Robbins JM 

PROVIDER: S-EPMC10132160 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature