Early-life iron deficiency persistently disrupts affective behaviour in mice.

ABSTRACT:

Background/objective

Iron deficiency (ID) is the most common nutrient deficiency, affecting two billion people worldwide, including about 30% of pregnant women. During gestation, the brain is particularly vulnerable to environmental insults, which can irrevocably impair critical developmental processes. Consequently, detrimental consequences of early-life ID for offspring brain structure and function have been described. Although early life ID has been associated with an increased long-term risk for several neuropsychiatric disorders, the effect on depressive disorders has remained unresolved.

Materials and methods

A mouse model of moderate foetal and neonatal ID was established by keeping pregnant dams on an iron-deficient diet throughout gestation until postnatal day 10. T

SUBMITTER: Gundacker A 

PROVIDER: S-EPMC10132221 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature