Epidemiological and microbiome associations of Clostridioides difficile carriage in infancy and early childhood.

ABSTRACT: There has been an increase in the prevalence of Clostridioides difficile (C. diff) causing significant economic impact on the health care system. Although toxigenic C. diff carriage is recognized in infancy, there is limited data regarding its longitudinal trends, associated epidemiolocal risk factors and intestinal microbiome characteristics. The objectives of our longitudinal cohort study were to investigate temporal changes in the prevalence of toxigenic C.diff colonization in children up to 2 years, associated epidemiological and intestinal microbiome characteristics. Pregnant mothers were enrolled prenatally, and serial stool samples were collected from their children for 2 years. 2608 serial stool samples were collected from 817 children. 411/817 (50%) were males, and 738/817 (90%) w

SUBMITTER: Mani J 

PROVIDER: S-EPMC10132246 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature