Hypothesis paper: the development of a regulatory layer in P2B autoinhibited Ca²⁺-ATPases may have facilitated plant terrestrialization and animal multicellularization.

ABSTRACT: With the appearance of plants and animals, new challenges emerged. These multicellular eukaryotes had to solve for example the difficulties of multifaceted communication between cells and adaptation to new habitats. In this paper, we are looking for one piece of the puzzle that made the development of complex multicellular eukaryotes possible with a focus on regulation of P2B autoinhibited Ca²⁺-ATPases. P2B ATPases pump Ca²⁺ out of the cytosol at the expense of ATP hydrolysis, and thereby maintain a steep gradient between the extra- and intracytosolic compartments which is utilized for Ca²⁺-mediated rapid cell signaling. The activity of these enzymes is regulated by a calmodulin (CaM)-responsive autoinhibitory region, which can be located in either termini

SUBMITTER: Steger A 

PROVIDER: S-EPMC10132250 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature