Hawthorn leaves flavonoids attenuate cardiac remodeling induced by simulated microgravity.

ABSTRACT:

Context

Hawthorn leaves are a kind of widely used medicinal plant in China. The major ingredient, hawthorn leaves flavonoids (HLF), have cardiotonic, cardioprotective, and vascular protective effects.

Objective

The study evaluated the protective role of HLF in cardiac remodelling and the underlying mechanisms under simulated microgravity by hindlimb unloading rats.

Materials and methods

Adult male Sprague-Dawley rats were divided into control, HLF, HU (hindlimb unloading) and HU + HLF groups (n = 8). After HU and daily intragastric administration at the dose of 100 mg/kg/d for 8 weeks, cardiac function and structure were evaluated by biochemical indices and histopathology. We identified the main active compounds and mechanisms involved in the cardioprotective e

SUBMITTER: Liu T 

PROVIDER: S-EPMC10132252 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature