Evolution and diversity of human adenoviruses isolated from patients with keratoconjunctivitis.

ABSTRACT:

Background and objectives

Human adenovirus type 8 is a highly contagious eye disease and is considered as the most common epidemic keratoconjunctivitis worldwide. The virus may alter the course of detection as mutations and recombination in surface antigens are associated with binding and pathogenesis in human adenovirus. The recognition of new recombinant human adenovirus has been based on sequencing of three genes, penton base, hexon and fiber.

Materials and methods

50 suspected samples of ocular keratoconjunctivitis were selected over 6 months. Following DNA extraction from isolates positive for cytopathic effect in each well, the complete sequences of hexon, fiber, and penton regions were performed on the genome of human adenovirus isolates using PCR. The sequences of ca

SUBMITTER: Karami C 

PROVIDER: S-EPMC10132332 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature