Study investigating executive function in schizophrenia patients and their unaffected siblings.

ABSTRACT:

Introduction

Schizophrenia (SCZ) is characterized by widespread cognitive impairments, such as executive functions. Most of the available research indicate that executive impairment has a certain genetic predisposition. Shared neuropathological characteristics of patients with SCZ and their siblings may reveal intermediate behavioral phenotypes that can be used to further characterize the illness.

Methods

Our study involved 32 SCZ patients, 32 unaffected siblings (US), and 33 persons as healthy controls (HCS). These three groups underwent a computerized version of the Wisconsin Card Sorting Test (WCST), and a battery of cognitive neuropsychological assessments. These tests also evaluate executive function and several cognitive domains.

Results

The performed study on S

SUBMITTER: Xu F 

PROVIDER: S-EPMC10132545 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature