Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathway.

ABSTRACT: During periods of energetic stress, Caenorhabditis elegans can execute a developmentally quiescent stage called "dauer", during which all germline stem cells undergo a G2 cell cycle arrest. In animals that lack AMP-activated protein kinase (AMPK) signalling, the germ cells fail to arrest, undergo uncontrolled proliferation, and lose their reproductive capacity upon recovery from this quiescent stage. These germline defects are accompanied by, and likely result from, an altered chromatin landscape and gene expression program. Through genetic analysis we identified an allele of tbc-7, a predicted RabGAP protein that functions in the neurons, which when compromised, suppresses the germline hyperplasia in the dauer larvae, as well as the post-dauer sterility and somatic defects characteristic

SUBMITTER: Wong C 

PROVIDER: S-EPMC10132661 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature