An ERK-dependent molecular switch antagonizes fibrosis and promotes regeneration in spiny mice (Acomys).

ABSTRACT: Although most mammals heal injured tissues and organs with scarring, spiny mice (Acomys) naturally regenerate skin and complex musculoskeletal tissues. Now, the core signaling pathways driving mammalian tissue regeneration are poorly characterized. Here, we show that, while immediate extracellular signal-regulated kinase (ERK) activation is a shared feature of scarring (Mus) and regenerating (Acomys) injuries, ERK activity is only sustained at high levels during complex tissue regeneration. Following ERK inhibition, ear punch regeneration in Acomys shifted toward fibrotic repair. Using single-cell RNA sequencing, we identified ERK-responsive cell types. Loss- and gain-of-function experiments prompted us to uncover fibroblast growth factor and ErbB signaling as u

SUBMITTER: Tomasso A 

PROVIDER: S-EPMC10132760 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature