Oligodendrocyte-mediated myelin plasticity and its role in neural synchronization.

ABSTRACT: Temporal synchrony of signals arriving from different neurons or brain regions is essential for proper neural processing. Nevertheless, it is not well understood how such synchrony is achieved and maintained in a complex network of time-delayed neural interactions. Myelin plasticity, accomplished by oligodendrocytes (OLs), has been suggested as an efficient mechanism for controlling timing in brain communications through adaptive changes of axonal conduction velocity and consequently conduction time delays, or latencies; however, local rules and feedback mechanisms that OLs use to achieve synchronization are not known. We propose a mathematical model of oligodendrocyte-mediated myelin plasticity (OMP) in which OLs play an active role in providing such feedback. This is achieved without usi

SUBMITTER: Pajevic S 

PROVIDER: S-EPMC10132807 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature