Pulmonary immune profiling of SIDS: impaired immune maturation and age-related cytokine imbalance.

ABSTRACT:

Background

For sudden infant death syndrome (SIDS), an impaired immunocompetence has been discussed for a long time. Cytokines and chemokines are soluble immune mediators (SIM) whose balance is essential for the immune status. We hypothesized that an imbalanced immune response might contribute to the etiology of SIDS.

Methods

We investigated 27 cytokines, chemokines, and growth factors in protein lysates of lungs derived from 29 SIDS cases and 15 control children deceased for other reasons.

Results

Except for the CCL5, no significant differences were detected in the lungs between SIDS cases with and without mild upper respiratory tract infections. In contrast, IL-1RA, IL-7, IL-13, and G-CSF were decreased in the merged SIDS cases compared to control cases without evid

SUBMITTER: Qu D 

PROVIDER: S-EPMC10132963 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature