Aeration strategy at birth does not impact carotid haemodynamics in preterm lambs.

ABSTRACT:

Background

The impact of different respiratory strategies at birth on the preterm lung is well understood; however, concerns have been raised that lung recruitment may impede cerebral haemodynamics. This study aims to examine the effect of three different ventilation strategies on carotid blood flow, carotid artery oxygen content and carotid oxygen delivery.

Methods

124-127-day gestation apnoeic intubated preterm lambs studied as part of a larger programme primarily assessing lung injury were randomised to positive pressure ventilation with positive end-expiratory pressure (PEEP) 8 cmH₂O (No-RM; n = 12), sustained inflation (SI; n = 15) or dynamic PEEP strategy (DynPEEP; maximum PEEP 14 or 20 cmH₂O, n = 41) at birth, followed by 90 min of standardised v

SUBMITTER: Dahm SI 

PROVIDER: S-EPMC10132978 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature