One-Lung Ventilation and Postoperative Pulmonary Complications After Major Lung Resection Surgery. A Multicenter Randomized Controlled Trial.

ABSTRACT:

Objectives

The effect of one-lung ventilation (OLV) strategy based on low tidal volume (TV), application of positive end-expiratory pressure (PEEP), and alveolar recruitment maneuvers (ARM) to reduce postoperative acute respiratory distress syndrome (ARDS) and pulmonary complications (PPCs) compared with higher TV without PEEP and ARM strategy in adult patients undergoing lobectomy or pneumonectomy has not been well established.

Design

Multicenter, randomized, single-blind, controlled trial.

Setting

Sixteen Italian hospitals.

Participants

A total of 880 patients undergoing elective major lung resection.

Interventions

Patients were randomized to receive lower tidal volume (LTV group: 4 mL/kg predicted body weight, PEEP of 5 cmH₂O, and ARMs) or

SUBMITTER: Piccioni F 

PROVIDER: S-EPMC10133024 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature