Chronic sleep loss sensitizes Drosophila melanogaster to nitrogen stress.

ABSTRACT: Chronic sleep loss profoundly impacts metabolic health and shortens lifespan, but studies of the mechanisms involved have focused largely on acute sleep deprivation.^1,2 To identify metabolic consequences of chronically reduced sleep, we conducted unbiased metabolomics on heads of three adult Drosophila short-sleeping mutants with very different mechanisms of sleep loss: fumin (fmn), redeye (rye), and sleepless (sss).^3,4,5,6,7 Common features included elevated ornithine and polyamines, with lipid, acyl-carnitine, and TCA cycle changes suggesting mitochondrial dysfunction. Studies of excretion demonstrate inefficient nitrogen elimination in adult sleep mutants,

SUBMITTER: Bedont JL 

PROVIDER: S-EPMC10133188 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature