A prospective study on linking diarrheagenic E. coli with stunted childhood growth in relation to gut microbiome.

ABSTRACT: Stunted growth is an emerging global challenge affecting children under the age of 5 years in low- and middle-income countries. Despite such a high global prevalence of stunting, the mechanism of pathogenesis and the role of associated gut microbiota is poorly understood. The present study was designed to investigate the association of pathogenic strains of E. coli with the residential gut microbiota of stunted growth children. A total of 64 stool sample were collected from children aged ≤ 5 years, and were processed for isolation and molecular characterization of diarrheagenic E. coli. Selected stool samples (n = 39 including three normal controls) were then analysed for microbial community profiling using 16S ribosomal RNA (rRNA) gene sequencing. Furthermore, associations between changes

SUBMITTER: Aziz I 

PROVIDER: S-EPMC10133260 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature