CanIsoNet: a database to study the functional impact of isoform switching events in diseases.

ABSTRACT:

Motivation

Alternative splicing, as an essential regulatory mechanism in normal mammalian cells, is frequently disturbed in cancer and other diseases. Switches in the expression of most dominant alternative isoforms can alter protein interaction networks of associated genes giving rise to disease and disease progression. Here, we present CanIsoNet, a database to view, browse and search isoform switching events in diseases. CanIsoNet is the first webserver that incorporates isoform expression data with STRING interaction networks and ClinVar annotations to predict the pathogenic impact of isoform switching events in various diseases.

Results

Data in CanIsoNet can be browsed by disease or searched by genes or isoforms in annotation-rich data tables. Various annotations for 11 

SUBMITTER: Karakulak T 

PROVIDER: S-EPMC10133402 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature