Establishment of an optimized guinea pig model of cisplatin-induced ototoxicity

ABSTRACT:

Background

Cisplatin is among the most effective antineoplastic agents and has revolutionized the treatment of many cancer diseases. However, one of its serious side effects is a progressive and irreversible hearing loss, occurring in both adults and children. For the development of otoprotective therapies that prevent this side effect, cisplatin-induced hearing loss animal models are indispensable. Due to the high toxicity of cisplatin, the establishment of such animal models is a difficult and time-consuming task. Here we introduce the detailed protocol of a sophisticated guinea pig model with a sufficient and permanent hearing loss induced by cisplatin. This manuscript is intended to provide guidance in the development of future cisplatin guinea pig models which may reduce the

SUBMITTER: Ahmadi N 

PROVIDER: S-EPMC10133486 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature