Genetic predisposition may not improve prediction of cardiac surgery-associated acute kidney injury.

ABSTRACT: Background: The recent integration of genomic data with electronic health records has enabled large scale genomic studies on a variety of perioperative complications, yet genome-wide association studies on acute kidney injury have been limited in size or confounded by composite outcomes. Genome-wide association studies can be leveraged to create a polygenic risk score which can then be integrated with traditional clinical risk factors to better predict postoperative complications, like acute kidney injury. Methods: Using integrated genetic data from two academic biorepositories, we conduct a genome-wide association study on cardiac surgery-associated acute kidney injury. Next, we develop a polygenic risk score and test the predictive utility within regressions controlling for

SUBMITTER: Douville NJ 

PROVIDER: S-EPMC10133500 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature