Mesenchymal stem cells therapy for acute kidney injury: A systematic review with meta-analysis based on rat model.

ABSTRACT: Objective: To systematically evaluate the efficacy of mesenchymal stem cells (MSCs) for acute kidney injury (AKI) in preclinical studies and to explore the optimal transplantation strategy of MSCs by network meta-analysis with the aim of improving the efficacy of stem cell therapy. Methods: Computer searches of PubMed, Web of Science, Cochrane, Embase, CNKI, Wanfang, VIP, and CBM databases were conducted until 17 August 2022. Literature screening, data extraction and quality evaluation were performed independently by two researchers. Results and Discussion: A total of 50 randomized controlled animal studies were included. The results of traditional meta-analysis showed that MSCs could significantly improve the renal function and injured renal tissue of AKI rats in diff

SUBMITTER: Wanyan P 

PROVIDER: S-EPMC10133560 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature