Age-related changes in prepulse inhibition of the startle response.

ABSTRACT:

Introduction

Acoustic prepulse inhibition of the startle response (PPI) is a phenomenon characterized by the reduction in the startle reflex caused by the presence of weak and brief stimulus before an intense and sudden stimulus (pulse). These phenomena can be observed in several species, but in humans it is commonly measured by the eyeblink using electromyography. PPI works as an operational measure of sensorimotor gating, which is the ability to suppress motor responses for sensory stimulus. Healthy aging is marked by several changes in neural processing, like inhibitory functioning decline. In this line, PPI measure can be a potential biomarker for changes related to the aging process.

Methods

In this research we aim to investigate if PPI is reduced with aging and if this

SUBMITTER: de Oliveira YG 

PROVIDER: S-EPMC10133574 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature