Association between Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphism (FokI-rs2228570) among Men with Anemia in Babylon Province, Iraq.

ABSTRACT: Vitamin D or calciferol is a fat-soluble vitamin that has a unique feature of synthesizing in the body mainly by exposure to UV from the sunlight and then transformed to 25 (OH) D by the liver and finally to a vital form 1,25-dihydroxyvitamin D by the kidneys. Vitamin D receptor gene polymorphism (FokI-rs2228570) has been proposed as the major cause of anemia. The present study aimed to discover the association between vitamin D deficiency and vitamin D receptor gene polymorphism (FokI-rs2228570) in patients with anemia. A total of 120 men with anemia and no kidney disorders have been compared with 60 healthy controls in the present case-control study. A single nucleotide polymorphism (SNP) FokI-rs2228570 was detected by PCR and PCR-RFLP techniques. Levels of serum vit

SUBMITTER: Mohamed AH 

PROVIDER: S-EPMC10133600 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature