Role of serum procalcitonin in the diagnosis and monitoring of treatment response in treatment-naive subjects with chronic pulmonary aspergillosis

ABSTRACT:

Background

Interferon-gamma (IFN-γ) down-regulates plasma procalcitonin (PCT), marker of inflammation. Chronic pulmonary aspergillosis (CPA) is associated with low IFN-γ levels. Thus, plasma PCT may be elevated in CPA and could have a role in diagnosing and monitoring treatment response in CPA. Herein, we investigate the diagnostic performance of plasma PCT in CPA.

Methods

We extracted the demographic, clinical, radiological, treatment outcomes, and plasma PCT levels of CPA subjects and controls (previously treated pulmonary tuberculosis with radiological abnormalities on CT chest [diseased controls] and treatment naïve active pulmonary tuberculosis [PTB]). We treated CPA subjects with six months of oral itraconazole. We took 0.25 ng/mL as a cut-off value for PCT. The stu

SUBMITTER: Sehgal I 

PROVIDER: S-EPMC10133757 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature