Hepatocyte mARC1 promotes fatty liver disease.

ABSTRACT:

Background & aims

Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25% worldwide, with significant public health consequences yet few effective treatments. Human genetics can help elucidate novel biology and identify targets for new therapeutics. Genetic variants in mitochondrial amidoxime-reducing component 1 (MTARC1) have been associated with NAFLD and liver-related mortality; however, its pathophysiological role and the cell type(s) mediating these effects remain unclear. We aimed to investigate how MTARC1 exerts its effects on NAFLD by integrating human genetics with in vitro and in vivo studies of mARC1 knockdown.

Methods

Analyses including multi-trait colocalisation and Mendelian randomisation were used to assess the genetic as

SUBMITTER: Lewis LC 

PROVIDER: S-EPMC10133763 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature