Physical fitness is associated with neural activity during working memory performance in major depressive disorder.

ABSTRACT:

Background

Deficits in cognition like working memory (WM) are highly prevalent symptoms related to major depressive disorder (MDD). Neuroimaging studies have described frontoparietal abnormalities in patients with MDD as a basis for these deficits. Based on research in healthy adults, it is hypothesized that increased physical fitness might be a protective factor for these deficits in MDD. However, the relationship between physical fitness and WM-related neural activity and performance has not been tested in MDD, to date. Understanding these associations could inform the development of physical exercise interventions in MDD.

Methods

Within a larger project, 111 (53female) MDD outpatients and 56 (34female) healthy controls performed an n-back task (0-, 1-, 2-, 3-back) during

SUBMITTER: Schwefel MK 

PROVIDER: S-EPMC10133876 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature