State-specific alterations in the neural computations underlying inhibitory control in women remitted from bulimia nervosa.

ABSTRACT: The neurocomputational processes underlying bulimia nervosa and its primary symptoms, out-of-control overeating and purging, are poorly understood. Research suggests that the brains of healthy individuals form a dynamic internal model to predict whether control is needed in each moment. This study tested the hypothesis that this computational process of inhibitory control is abnormally affected by metabolic state (being fasted or fed) in bulimia nervosa. A Bayesian ideal observer model was fit to behavioral data acquired from 22 women remitted from bulimia nervosa and 20 group-matched controls who completed a stop-signal task during two counterbalanced functional MRI sessions, one after a 16 h fast and one after a meal. This model estimates participants' trial-by-trial updating of the prob

SUBMITTER: Berner LA 

PROVIDER: S-EPMC10133909 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature