Efficacy of Buzhong Yiqi decoction on benign prostatic hyperplasia and its possible mechanism.

ABSTRACT:

Objective

To explored the mechanism of Buzhong Yigi decoction ( BZYQD) in inhibiting prostatic cell proliferation effect.

Methods

The compounds of BZYQD consisted with eight herbs were searched in TCMSP databases and the putative targets of BZYQD were collected in Drugbank database. Then, "Benign prostatic hyperplasia" (BPH) was used to find the targets based on the GeneCards, Online Mendelian Inheritance in Man (OMIM) and Therapeutic Target Database (TTD) databases, and they were further used to collect further collect the intersection targets between BZYQD and BPH by counter-selection. Next, Herb-Compound-Target-Disease network was constructed by Cytoscape software and protein interaction network was built by Search tool for recurring instances of neighbouring genes (STRIN

SUBMITTER: Lihua J 

PROVIDER: S-EPMC10133955 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature