Intracranial and Extracranial Progression and Their Correlation With Overall Survival After Stereotactic Radiosurgery in a Multi-institutional Cohort With Brain Metastases.

ABSTRACT:

Importance

Clinical trials for metastatic malignant neoplasms are increasingly being extended to patients with brain metastases. Despite the preeminence of progression-free survival (PFS) as a primary oncologic end point, the correlation of intracranial progression (ICP) and extracranial progression (ECP) events with overall survival (OS) is poorly understood for patients with brain metastases following stereotactic radiosurgery (SRS).

Objective

To determine the correlation of ICP and ECP with OS among patients with brain metastases completing an initial SRS course.

Design, setting, and participants

This multi-institutional retrospective cohort study was conducted from January 1, 2015, to December 31, 2020. We included patients who completed an initial course of SRS f

SUBMITTER: Carpenter DJ 

PROVIDER: S-EPMC10134007 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature