Validation of the Hidradenitis Suppurativa Investigator Global Assessment: A Novel Hidradenitis Suppurativa-Specific Investigator Global Assessment for Use in Interventional Trials.

ABSTRACT:

Importance

Few simplified instruments exist for use in hidradenitis suppurativa (HS) trials.

Objective

To assess psychometric properties of the Hidradenitis Suppurativa Investigator Global Assessment (HS-IGA) score using a clinical trial data set.

Design, setting, and participants

This retrospective analysis of a phase 2 randomized double-blind, placebo-controlled, active-reference arm trial (UCB HS0001) included adults with moderate-to-severe HS.

Exposures

Trial participants were randomized at baseline to receive bimekizumab, adalimumab, or placebo.

Main outcomes and measures

The HS-IGA score at prespecified time points up to 12 weeks after randomization.

Results

The HS-IGA score showed strong convergent validity with IHS4 and HS-PhGA scores at b

SUBMITTER: Garg A 

PROVIDER: S-EPMC10134037 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature