Effect of Dapagliflozin on Total Heart Failure Events in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the DELIVER Trial.

ABSTRACT:

Importance

In the Dapagliflozin Evaluation to Improve the Lives of Patients With Preserved Ejection Fraction Heart Failure (DELIVER) trial, dapagliflozin reduced the risk of time to first worsening heart failure (HF) event or cardiovascular death in patients with HF with mildly reduced or preserved ejection fraction (EF).

Objective

To evaluate the effect of dapagliflozin on total (ie, first and recurrent) HF events and cardiovascular death in this population.

Design, setting, and participants

In this prespecified analysis of the DELIVER trial, the proportional rates approach of Lin, Wei, Yang, and Ying (LWYY) and a joint frailty model were used to examine the effect of dapagliflozin on total HF events and cardiovascular death. Several subgroups were examined to test f

SUBMITTER: Jhund PS 

PROVIDER: S-EPMC10134044 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature