Potential Inhibitory Biomolecular Interactions of Natural Compounds With Different Molecular Targets of Diabetes.

ABSTRACT: Type II diabetes is an endemic disease and is responsible for approximately 90% to 95% of diabetes cases. The pathophysiological distortions are majorly β-cell dysfunction, insulin resistance, and long-term inflammation, which all progressively unsettle the control of blood glucose levels and trigger microvascular and macrovascular complications. The diverse pathological disruptions which patients with type II diabetes mellitus exhibit precipitate the opinion that different antidiabetic agents, administered in combination, might be required to curb this menace and maintain normal blood glucose. To this end, natural compounds were screened to identify small molecular weight compounds with inhibitory effects on protein tyrosine phosphatase 1B (PTP1B), dipeptidyl-peptidase-4 (DPP-4), and α-am

SUBMITTER: Akinnusi PA 

PROVIDER: S-EPMC10134171 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature