Venlafaxine XR treatment for older patients with major depressive disorder: decision trees for when to change treatment.

ABSTRACT:

Background

Predictors of antidepressant response in older patients with major depressive disorder (MDD) need to be confirmed before they can guide treatment.

Objective

To create decision trees for early identification of older patients with MDD who are unlikely to respond to 12 weeks of antidepressant treatment, we analysed data from 454 older participants treated with venlafaxine XR (150-300 mg/day) for up to 12 weeks in the Incomplete Response in Late-Life Depression: Getting to Remission study.

Methods

We selected the earliest decision point when we could detect participants who had not yet responded (defined as >50% symptom improvement) but would do so after 12 weeks of treatment. Using receiver operating characteristic models, we created two decision trees to min

SUBMITTER: Kim HK 

PROVIDER: S-EPMC10134194 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature