Association between peripheral blood cytopenia and cancer mortality: A race-specific risk factor for cancer death.

ABSTRACT:

Background

Cytopenia is associated with cancer through mechanisms including clonal hematopoiesis and chronic inflammation. Cytopenia is more prevalent in Black people but its relationship with racial disparities in cancer mortality is unknown.

Methods

Cytopenia was defined in 19,028 Black and White participants recruited between 2003 and 2007 for the REasons for Geographic and Racial Differences in Stroke cohort, based on age-, sex-, and race-adjusted ranges for blood counts. Cancer death was ascertained from Social Security Death and National Death Indexes. Multivariable Cox models estimated the risk of cancer mortality associated with cytopenia, adjusting for demographics (model1), anemia and cancer risk factors (model2), and socioeconomics (model3). Racial differences in

SUBMITTER: Adrianzen-Herrera DA 

PROVIDER: S-EPMC10134255 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature