Psychiatric risk factors for chronic high-dose opioid prescribing: register-based cohort study.

ABSTRACT:

Background

Chronic high-dose (CHD) prescription opioid use is a major public health concern. Although CHD opioid use has been associated with psychiatric disorders, the causality could go both ways. Some studies have already linked psychiatric disorders to an increased risk of transitioning to chronic opioid use, and longitudinal data identifying psychiatric disorders as predictors of CHD opioid use could shed further light on this issue.

Aims

To prospectively examine the relationship between the presence of a psychiatric disorder and subsequent development of CHD opioid use in primary care patients newly receiving opioids.

Method

Data were included from 137 778 primary care patients in The Netherlands. Cox regression modelling was used to examine the association betw

SUBMITTER: van der Hoorn MMC 

PROVIDER: S-EPMC10134259 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature