Long noncoding RNA SNHG4 promotes the malignant progression of hepatocellular carcinoma through the miR-211-5p/CREB5 axis.

ABSTRACT:

Background and aims

Hepatocellular carcinoma (HCC) is one of the main death-leading malignant tumors which deserve in-depth explorations to uncover the underlying molecular mechanisms. Plenty of proofs have revealed that long noncoding RNAs (lncRNAs) participate in malignancy and progression of HCC. Nevertheless, the definite role of lncRNA-SNHG4 in HCC remains vague.

Methods

To figure out the role of SNHG4 in HCC, the bioinformatics analysis and functional assays and in vivo assay were performed.

Results

Our findings demonstrated that the data from The Cancer Genome Atlas (TCGA) displayed that the higher expression of lncRNA SNHG4 was detected in HCC tissues, which predicted the poor prognosis. The upregulation of SNHG4 was positively associated with worse clinicopat

SUBMITTER: Qiu J 

PROVIDER: S-EPMC10134289 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature