KLRF1, a novel marker of CD56^bright NK cells, predicts improved survival for patients with locally advanced bladder cancer.

ABSTRACT:

Background

Bladder tumor-infiltrating CD56^bright NK cells are more tumor cytotoxic than their CD56^dim counterparts. Identification of NK cell subsets is labor-intensive and has limited utility in the clinical setting. Here, we sought to identify a surrogate marker of bladder CD56^bright NK cells and to test its prognostic significance.

Methods

CD56^bright and CD56^dim NK cells were characterized with the multiparametric flow (n = 20) and mass cytometry (n = 21) in human bladder tumors. Transcriptome data from bladder tumors (n = 351) profiled by The Cancer Genome Atlas (TCGA) were analyzed. The expression levels of individual markers in intratumoral CD56^bright and CD56^dim NK cells were visualized in tS

SUBMITTER: Mukherjee N 

PROVIDER: S-EPMC10134305 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature