RMI2 is a novel prognostic and predictive biomarker for breast cancer.

ABSTRACT:

Background

RecQ-mediated genome instability 2 (RMI2) maintains genome stability by promoting DNA damage repair. It has been reported to accelerate the progression of several tumors. However, the functional mechanism of RMI2 in breast cancer remains unclear.

Methods

Gene expression profiles were obtained from TCGA, GTEx, and GEO databases. The expression of RMI2 and its prognostic value in breast cancer was explored. In addition, we calculated pooled standardized mean deviation (SMD) and performed a summary receiver operating characteristic (sROC) curve analysis to further determine RMI2 expression status and diagnostic significance. The functions and related signaling pathways were investigated based on GO and KEGG analyses. The PPI network was constructed by combining the S

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10134310 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature