Characterization of the gene signature correlated with favorable response to chemoradiotherapy in rectal cancer: A hypothesis-generating study.

ABSTRACT:

Purpose

This study aimed to define the gene signature associated with response to neoadjuvant chemoradiotherapy (nCRT), or chemoradiosensitivity (CRS) signature, in rectal cancer, and investigate the correlation between the CRS signature and characteristics of tumor.

Materials and methods

Three public microarray datasets of pre-nCRT rectal cancer were used to discover and validate the CRS signature, and the pathway analysis of the CRS signature was performed. Patients in The Cancer Genome Atlas (TCGA) dataset were stratified according to the CRS signature enrichment score, and mutational profile and proportions of infiltrated immune cells were compared.

Results

In the discovery dataset (GSE53781), 95 genes were upregulated in complete responders compared to non-comple

SUBMITTER: Jeon SH 

PROVIDER: S-EPMC10134325 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature