Par14 interacts with the androgen receptor, augmenting both its transcriptional activity and prostate cancer proliferation.

ABSTRACT:

Background

Prostate cancer (PCa) is a major cause of cancer morbidity and mortality for men globally, and androgen signaling clearly drives its onset and progression. Androgen receptor (AR) regulation is complex and remains elusive, despite several studies tackling these issues. Therefore, elucidating the mechanism(s) underlying AR regulation is a potentially promising approach to suppressing PCa.

Methods

We report that Par14, one isoform of the prolyl isomerases homologous to Pin1, is a critical regulator of AR transcriptional activity and is essential for PCa cell growth.

Results

Par14 was shown to be overexpressed in PCa, based on analyses of deposited data. Importantly, overexpression of Par14 significantly enhanced androgen-sensitive LNCap cell growth. In contras

SUBMITTER: Naito M 

PROVIDER: S-EPMC10134346 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature